Description

(2Z)-1-[4-(Difluoromethoxy)Phenyl]-3-(Dimethylamino)Prop-2-En-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its specific enone structure with difluoromethoxy and dimethylamino substituents. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), where its precise stereochemistry and functional groups are essential. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of novel drug candidates, especially those targeting central nervous system (CNS) disorders or inflammatory pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new chemical entities.
• Process Chemistry Development: Serves as a standard or starting material for scaling up and optimizing synthetic routes for API manufacturing.
• Chemical Synthesis: Employed in organic synthesis for constructing complex molecules via reactions involving its α,β-unsaturated ketone moiety.
• Reference Standard: Utilized as an analytical reference standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(2Z)-1-[4-(Difluoromethoxy)Phenyl]-3-(Dimethylamino)Prop-2-En-1-One
CAS No.	832738-01-9
Molecular Formula	C₁₂H₁₃F₂NO₂
Molecular Weight	241.24 g/mol
Synonyms	1-[4-(Difluoromethoxy)phenyl]-3-(dimethylamino)-2-propen-1-one, (Z)-1-[4-(Difluoromethoxy)phenyl]-3-(dimethylamino)prop-2-en-1-one, (2Z)-1-[4-(Difluoromethoxy)phenyl]-3-(dimethylamino)-2-propen-1-one, 2-Propen-1-one, 1-[4-(difluoromethoxy)phenyl]-3-(dimethylamino)-, (2Z)-, Difluoromethoxy Chalcone Derivative, Dimethylamino Enone Intermediate, CAS 832738-01-9
EINECS	Contact for details

Quality Control

Our (2Z)-1-[4-(Difluoromethoxy)Phenyl]-3-(Dimethylamino)Prop-2-En-1-One is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP standards for pharmaceutical applications, and our quality protocols are designed to meet the rigorous demands of global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, open flames, and incompatible materials. The container should be kept tightly sealed when not in use to protect against moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.