Description

1-(3,4-Dichloro-Phenyl)-4,4-Difluorobutane-1,3-Dione is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluorinated β-diketone structure. This compound matters as a critical building block in modern synthetic organic chemistry, enabling the development of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the synthesis of complex molecules targeting a range of therapeutic and crop protection applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Serves as a versatile scaffold for developing new-generation herbicides and fungicides, leveraging the dichlorophenyl and difluoro motifs for enhanced biological activity.
• Chemical Research & Development: Used in academic and industrial R&D labs for exploring new synthetic methodologies, particularly in fluorination chemistry and heterocycle formation.
• Ligand and Complex Formation: Its β-diketone moiety makes it a suitable candidate for chelating metal ions, useful in catalysis and material science applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	1-(3,4-Dichloro-Phenyl)-4,4-Difluorobutane-1,3-Dione
CAS No.	832737-94-7
Molecular Formula	C10H6Cl2F2O2
Molecular Weight	267.06 g/mol
Synonyms	4,4-Difluoro-1-(3,4-dichlorophenyl)butane-1,3-dione; 3,4-Dichlorophenyl 4,4-difluoro-3-oxobutanoate; 1-(3,4-Dichlorophenyl)-4,4-difluoro-1,3-butanedione; 4,4-Difluoro-1-(3,4-dichlorophenyl)-1,3-butanedione; 3,4-Dichloro-α,α-difluoroacetoacetophenone; DFDB; DCP-DFBD
EINECS	Contact for details

Quality Control

Our 1-(3,4-Dichloro-Phenyl)-4,4-Difluorobutane-1,3-Dione is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical intermediate applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support compliance with relevant regulatory frameworks, including ICH guidelines and cGMP where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.