Description

1-(4-Difluoromethoxy-3-Methoxy-Phenyl)-4,4,4-Trifluoro-Butane-1,3-Dione is a specialized fluorinated diketone compound that serves as a critical advanced intermediate in modern synthetic chemistry. Its unique molecular architecture, featuring difluoromethoxy and trifluoromethyl groups, provides exceptional utility for introducing fluorine motifs into target molecules, thereby enhancing their metabolic stability, lipophilicity, and bioavailability. This high-value building block is essential for research and development teams in the pharmaceutical and agrochemical sectors seeking to innovate and optimize next-generation active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved pesticidal activity and environmental persistence.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and coatings with enhanced chemical resistance and thermal stability.
• Ligand and Catalyst Development: Employed in organometallic chemistry for creating novel fluorinated ligands that modulate catalyst activity and selectivity in asymmetric synthesis.
• Fluorine Chemistry Building Block: A versatile synthon for constructing complex molecules containing the pharmacologically privileged difluoromethoxy and β-diketone functional groups.

Basic Information

Product Name	1-(4-Difluoromethoxy-3-Methoxy-Phenyl)-4,4,4-Trifluoro-Butane-1,3-Dione
CAS No.	832737-64-1
Molecular Formula	C13H11F5O4
Molecular Weight	326.22 g/mol
Synonyms	4,4,4-Trifluoro-1-[4-(difluoromethoxy)-3-methoxyphenyl]butane-1,3-dione; 1-(4-(Difluoromethoxy)-3-methoxyphenyl)-4,4,4-trifluorobutane-1,3-dione; 4-(Difluoromethoxy)-3-methoxybenzoylacetone trifluoromethyl derivative; DFMP-TFBD; CAS 832737-64-1
EINECS	Contact for details

Quality Control

Our production of 1-(4-Difluoromethoxy-3-Methoxy-Phenyl)-4,4,4-Trifluoro-Butane-1,3-Dione adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization using HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting critical parameters. Our quality system is designed to support cGMP compliance for pharmaceutical applications, ensuring traceability and reliability for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and potential degradation. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.