Description

Dichloro[1,3-Bis(2,4,6-Trimethylphenyl)-2-Imidazolidinylidene][(Tricyclohexylphosphoranyl)Methylidene]Ruthenium(II) Tetrafluoroborate is a highly active, second-generation Grubbs-Hoveyda type olefin metathesis catalyst. This compound is valued for its exceptional stability, functional group tolerance, and high turnover numbers, enabling efficient and selective carbon-carbon double bond formation. It is an essential reagent for researchers and process chemists in advanced organic synthesis, particularly for the production of pharmaceuticals, fine chemicals, and novel polymeric materials.

Application

• Ring-Closing Metathesis (RCM): For the synthesis of medium to large cyclic compounds, including macrocycles and heterocycles, crucial in natural product and pharmaceutical synthesis.
• Cross-Metathesis (CM): For the selective coupling of two different olefins to create complex molecular architectures and functionalized intermediates.
• Ring-Opening Metathesis Polymerization (ROMP): For the production of specialized polymers with unique mechanical and chemical properties, used in advanced materials science.
• Ene-yne Metathesis: For the construction of 1,3-diene structures, a valuable transformation in synthetic organic chemistry.
• Pharmaceutical Intermediate Synthesis: Enabling key bond-forming steps in the scalable production of active pharmaceutical ingredients (APIs).
• Fine Chemical and Agrochemical Manufacturing: For creating complex, high-value molecules with precise stereochemical control.
• Academic and Industrial R&D: As a benchmark catalyst for developing new metathesis methodologies and exploring novel chemical space.

Basic Information

Product Name	Dichloro[1,3-Bis(2,4,6-Trimethylphenyl)-2-Imidazolidinylidene][(Tricyclohexylphosphoranyl)Methylidene]Ruthenium(II) Tetrafluoroborate
CAS No.	832146-68-6
Molecular Formula	C46H72BCl2F4N2PRu
Molecular Weight	936.85 g/mol
Synonyms	Grubbs-Hoveyda Catalyst 2nd Generation; Hoveyda-Grubbs Catalyst 2nd Gen; (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(o-isopropoxyphenylmethylene)ruthenium(II) Tetrafluoroborate Salt; Dichloro(o-isopropoxyphenylmethylene)(1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)ruthenium(II) Tetrafluoroborate; HG II Tetrafluoroborate Salt; [RuCl2(IMesH2)(C6H4-o-OiPr)]BF4; Zhan Catalyst 1B
EINECS	Contact for details

Quality Control

Our Dichloro[1,3-Bis(2,4,6-Trimethylphenyl)-2-Imidazolidinylidene][(Tricyclohexylphosphoranyl)Methylidene]Ruthenium(II) Tetrafluoroborate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and performance in standard metathesis tests. We adhere to cGMP guidelines where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent decomposition. This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep the container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	Dark green to brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in dichloromethane, toluene, THF
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.