Description

1-Methyl-5-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl]Piperazine is a high-value, advanced pharmaceutical intermediate featuring a piperazine core linked to a pyridine boronic ester pinacol group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl structures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between the boronic ester and aryl/heteroaryl halides under palladium catalysis.
• Kinase Inhibitor Development: Used in constructing heterocyclic scaffolds common in oncology and anti-inflammatory drug research.
• Agrochemical Synthesis: Serves as an intermediate for creating novel herbicides and fungicides with enhanced efficacy.
• Material Science Research: Potential precursor for organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in creating tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	1-Methyl-5-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl]Piperazine
CAS No.	832114-09-7
Molecular Formula	C16H26BN3O2
Molecular Weight	303.21 g/mol
Synonyms	1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine; 2-(1-Methylpiperazin-4-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(4-methylpiperazin-1-yl)pyridine; 1-Methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine; 2-(4-Methyl-1-piperazinyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 832114-09-7; 1-Methyl-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine
EINECS	Contact for details

Quality Control

Our 1-Methyl-5-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl]Piperazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.