Description

(4-Methyl-Piperazine-1-Yl)-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Phenyl]-Methanone is a high-value pharmaceutical intermediate and chemical building block featuring a piperazine scaffold linked to a boronic ester pinacol group. This compound matters as a critical synthon in modern medicinal chemistry, enabling efficient Suzuki-Miyaura cross-coupling reactions for the construction of complex biaryl structures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring biaryl linkages.
• Suzuki-Miyaura Cross-Coupling: The boronic ester moiety serves as a stable, reactive handle for palladium-catalyzed coupling with aryl halides, a cornerstone reaction in drug discovery.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and herbicides.
• Ligand and Catalyst Development: The piperazine moiety can be utilized to create novel ligands for catalysis or functional materials.
• Chemical Biology Probes: Useful for creating tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	(4-Methyl-Piperazine-1-Yl)-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Phenyl]-Methanone
CAS No.	832114-06-4
Molecular Formula	C18H27BN2O3
Molecular Weight	330.23 g/mol
Synonyms	4-(4-Methylpiperazine-1-carbonyl)phenylboronic acid pinacol ester; 1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]-4-methylpiperazine; 4-Methyl-1-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbonyl]piperazine; 4-(4-Methylpiperazine-1-carbonyl)benzeneboronic acid pinacol ester; (4-(4-Methylpiperazine-1-carbonyl)phenyl)boronic acid pinacol ester; 832114-06-4; 4-Methylpiperazine-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone
EINECS	Contact for details

Quality Control

Our (4-Methyl-Piperazine-1-Yl)-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Phenyl]-Methanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity suitable for sensitive cross-coupling reactions. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.