Description

2-Trifluoromethyl-5-Fluorobenzyl Chloride is a high-value fluorinated benzyl chloride derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary commercial value lies in enabling the precise introduction of a reactive chloromethyl group adjacent to electron-withdrawing trifluoromethyl and fluorine substituents, facilitating the construction of complex molecular architectures. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials sectors, where it is used to synthesize novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drugs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving charge transport and device efficiency.
• Polymer & Resin Modification: Employed to introduce fluorinated benzyl groups into polymer chains, enhancing material properties such as chemical resistance, thermal stability, and surface characteristics.
• Cross-Coupling Reactions: A versatile electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) for creating biaryl structures common in many advanced materials.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry groups exploring new synthetic routes and novel fluorinated compounds.

Basic Information

Product Name	2-Trifluoromethyl-5-Fluorobenzyl Chloride
CAS No.	832113-94-7
Molecular Formula	C8H5ClF4
Molecular Weight	212.57 g/mol
Synonyms	1-(Chloromethyl)-2-(trifluoromethyl)-5-fluorobenzene; 5-Fluoro-2-(trifluoromethyl)benzyl Chloride; α-Chloro-5-fluoro-α,α,α-trifluoro-o-xylene; (5-Fluoro-2-(trifluoromethyl)phenyl)methyl Chloride; 2-(Trifluoromethyl)-5-fluorobenzyl Chloride; 5-Fluoro-α,α,α-trifluoro-o-tolyl Chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Trifluoromethyl-5-Fluorobenzyl Chloride is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity, consistency, and traceability. Our standard quality protocol includes identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment. We support compliance with cGMP, ISO, and REACH requirements as needed for our global customer base.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.