Description

2-Aminopyridine-5-Boronic Acid, Pinacol Ester is a high-value, protected boronic acid derivative essential for modern synthetic chemistry. Its primary value lies in serving as a key synthetic intermediate in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This compound is particularly critical for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in kinase inhibitor and heterocyclic compound libraries.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific pyridine-based scaffolds.
• Material Science Research: Employed in the creation of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and activity-based protein profiling (ABPP) reagents.
• Catalyst & Ligand Development: Serves as a precursor for synthesizing novel bidentate ligands used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex organic molecules on scale.

Basic Information

Product Name	2-Aminopyridine-5-Boronic Acid, Pinacol Ester
CAS No.	827614-64-2
Molecular Formula	C11H17BN2O2
Molecular Weight	220.08 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (2-Aminopyridin-5-yl)boronic acid pinacol ester; 2-Amino-5-pyridineboronic acid pinacol ester; 5-Boronic acid pinacol ester-2-aminopyridine; 2-Amino-5-(pinacolatoboryl)pyridine; 2-Pyridinamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our 2-Aminopyridine-5-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.