Description

Endo-3-Azabicyclo[3.1.0]Hexane-6-Methanol CAS NO 827599-22-4 is a high-purity, advanced pharmaceutical intermediate featuring a unique, strained bicyclic scaffold. This compound is of significant commercial value as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the central nervous system (CNS) and antiviral therapeutic areas. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates targeting neurological disorders.
• Organic Synthesis Building Block: Utilized in medicinal chemistry for constructing complex, three-dimensional molecular architectures due to its rigid bicyclic structure.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in asymmetric catalysis.
• Agrochemical Research: Potential intermediate in the synthesis of new generation pesticides and herbicides.
• Academic and R&D: Used in fundamental chemical research to study strained ring systems and reaction mechanisms.

Basic Information

Product Name	Endo-3-Azabicyclo[3.1.0]Hexane-6-Methanol
CAS No.	827599-22-4
Molecular Formula	C7H11NO
Molecular Weight	125.17 g/mol
Synonyms	6-(Hydroxymethyl)-3-azabicyclo[3.1.0]hexane (endo-); (1S,5R,6R)-6-(Hydroxymethyl)-3-azabicyclo[3.1.0]hexane; 3-Azabicyclo[3.1.0]hexane-6-methanol, endo-; Bicyclo[3.1.0]hexane-6-methanol, 3-aza-, endo-; AZ-216; A key intermediate for BMS-986165; Tyk2 Inhibitor Intermediate.
EINECS	Contact for details

Quality Control

We supply Endo-3-Azabicyclo[3.1.0]Hexane-6-Methanol under a stringent quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and enantiomeric excess where specified. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all critical quality attributes. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.