Description

2-(Pyrrolidin-1-Yl)-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide is a high-value, advanced pharmaceutical intermediate featuring a key boronic ester functional group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is an essential building block for research and development chemists in the pharmaceutical and agrochemical industries, enabling the synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a versatile organoboron partner for palladium-catalyzed carbon-carbon bond formation with aryl halides or triflates.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science: Potential building block for creating organic electronic materials and advanced polymers.
• Chemical Biology Probes: Can be utilized to develop molecular probes for studying biological processes and target identification.

Basic Information

Product Name	2-(Pyrrolidin-1-Yl)-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide
CAS No.	825630-80-6
Molecular Formula	C20H31BN2O3
Molecular Weight	358.29 g/mol
Synonyms	N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2-(1-pyrrolidinyl)acetamide; 2-Pyrrolidin-1-yl-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; 4-(2-(Pyrrolidin-1-yl)acetamido)phenylboronic acid pinacol ester; 825630-80-6; BRN 12511913
EINECS	Contact for details

Quality Control

Our 2-(Pyrrolidin-1-Yl)-n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >95% by HPLC), and impurity profiles. We support cGMP compliance for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize condensation and hydrolysis of the boronic ester.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.