Description

1-Iodo-2,5-Difluoro Benzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both iodine and fluorine substituents, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and materials science sectors for applications in cross-coupling reactions and the development of novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorine atoms and iodine handles for further functionalization via cross-coupling reactions like Suzuki or Sonogashira couplings.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides, where the difluoro and iodo groups can modulate biological activity and stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating fluorinated aromatic cores in advanced electronic materials, contributing to improved performance in displays and lighting.
• Cross-Coupling Reactions: The iodine atom acts as an excellent leaving group in palladium-catalyzed cross-coupling reactions, enabling the formation of new carbon-carbon bonds.
• Fluorine Chemistry Research: An essential reagent for studying structure-activity relationships (SAR) and for the synthesis of more complex, multi-fluorinated aromatic systems.
• Ligand & Catalyst Development: Utilized in the preparation of specialized ligands and catalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	1-Iodo-2,5-Difluoro Benzene
CAS No.	824390-18-3
Molecular Formula	C6H3F2I
Molecular Weight	255.99 g/mol
Synonyms	2,5-Difluoroiodobenzene; 1,4-Difluoro-2-iodobenzene; 2-Iodo-1,4-difluorobenzene; Benzene, 1-iodo-2,5-difluoro-; Iodobenzene, 2,5-difluoro-; 2,5-Difluoro-1-iodobenzene; 2,5-Difluorophenyl iodide
EINECS	Contact for details

Quality Control

Our 1-Iodo-2,5-Difluoro Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures material consistency and reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.