Description

6,8-Methanoisoquinoline-3-carboxaldehyde, 5,6,7,8-tetrahydro-7,7-dimethyl-, (6R,8R)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules, offering a precise chiral scaffold for medicinal chemistry research and development. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers focused on creating novel active pharmaceutical ingredients (APIs) and other bioactive compounds. CAS No. 821774-78-1.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Asymmetric Synthesis: Provides a rigid, bicyclic framework with defined stereocenters for constructing complex molecular architectures.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals requiring high stereochemical purity.
• Contract Research & Manufacturing (CRAM): Supplied to organizations offering custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for methodological development in organic and heterocyclic chemistry.

Basic Information

Product Name	6,8-Methanoisoquinoline-3-carboxaldehyde, 5,6,7,8-tetrahydro-7,7-dimethyl-, (6R,8R)-
CAS No.	821774-78-1
Molecular Formula	C₁₄H₁₇NO
Molecular Weight	215.29 g/mol
Synonyms	(6R,8R)-5,6,7,8-Tetrahydro-7,7-dimethyl-6,8-methanoisoquinoline-3-carboxaldehyde; (6R,8R)-7,7-Dimethyl-5,6,7,8-tetrahydro-6,8-methanoisoquinoline-3-carbaldehyde; 821774-78-1; (6R,8R)-THIQ aldehyde derivative; Chiral tetrahydro-methanoisoquinoline carboxaldehyde
EINECS	Contact for details

Quality Control

Our 6,8-Methanoisoquinoline-3-carboxaldehyde, 5,6,7,8-tetrahydro-7,7-dimethyl-, (6R,8R)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We adhere to cGMP principles where applicable to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.