Description

tert-Butyl Methyl(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Carbamate is a high-purity, protected boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in providing a stable, reactive handle for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced materials science who require reliable, high-quality intermediates for their R&D and production processes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biphenyl or substituted phenyl motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science Research: Building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Intermediate for synthesizing sophisticated ligands and organometallic catalysts.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized in the construction of bifunctional molecules for targeted protein degradation.
• Academic & Industrial R&D: A versatile reagent for method development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Product Name	tert-Butyl Methyl(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Carbamate
CAS No.	817618-57-8
Molecular Formula	C18H28BNO4
Molecular Weight	333.23 g/mol
Synonyms	Boc-Protected 3-Pinacolboron Benzylamine Derivative; tert-Butyl N-Methyl-N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate; 3-((tert-Butoxycarbonyl)(methyl)amino)phenylboronic acid pinacol ester; N-Boc-N-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; Methyl(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl Methyl(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Carbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and LC-MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ISO standards for advanced intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.