Description

5-(Trifluoromethyl)-2,3-Dihydro-1H-Inden-1-Amine is a high-value, fluorinated indane derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring a trifluoromethyl group and a primary amine on a fused ring system, makes it an essential intermediate for developing novel pharmaceuticals and agrochemicals with enhanced metabolic stability and bioavailability. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of central nervous system (CNS) active drugs, enzyme inhibitors, and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Incorporated into the design of novel organic electronic materials and liquid crystals.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules at various scales.

Basic Information

Product Name	5-(Trifluoromethyl)-2,3-Dihydro-1H-Inden-1-Amine
CAS No.	808756-84-5
Molecular Formula	C10H10F3N
Molecular Weight	201.19 g/mol
Synonyms	1-Amino-5-(trifluoromethyl)indane; 5-(Trifluoromethyl)-1-indanamine; 5-(Trifluoromethyl)indan-1-amine; 1-Indanamine, 5-(trifluoromethyl)-; 808756-84-5; 5-Trifluoromethyl-2,3-dihydro-1H-inden-1-amine; α,α,α-Trifluoro-2,3-dihydro-1H-indene-5-methanamine
EINECS	Contact for details

Quality Control

Our production of 5-(Trifluoromethyl)-2,3-Dihydro-1H-Inden-1-Amine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization using techniques including HPLC, GC, NMR, and MS. We provide detailed Certificates of Analysis (COA) with every shipment, documenting identity, purity, and impurity profiles. Our quality system is designed to support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.