Description

Acetic Acid, Difluoro[(2-Hydroxyethyl)Thio]-, Ethyl Ester (9Ci) is a specialized organofluorine and sulfur-containing building block with the CAS number 804476-64-0. This compound is valued for its unique bifunctional reactivity, offering both a difluoroacetate ester and a thioether-alcohol moiety in a single molecule. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates. The presence of fluorine atoms can impart desirable metabolic stability and bioavailability to target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those requiring fluorinated motifs for enhanced potency and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the difluoroacetate group can be a critical pharmacophore.
• Advanced Material Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers and materials with specific surface properties.
• Chemical Biology Probe Development: Utilized to create tagged or modified biochemical tools for studying enzyme mechanisms and protein interactions.
• Ligand and Catalyst Synthesis: The thioether and hydroxyl groups make it a useful precursor for constructing complex chelating ligands and organocatalysts.

Basic Information

Product Name	Acetic Acid, Difluoro[(2-Hydroxyethyl)Thio]-, Ethyl Ester (9Ci)
CAS No.	804476-64-0
Molecular Formula	C6H10F2O3S
Molecular Weight	200.21 g/mol
Synonyms	Ethyl 2-[(2-hydroxyethyl)thio]-2,2-difluoroacetate; 2-[(2-Hydroxyethyl)thio]-2,2-difluoroacetic Acid Ethyl Ester; Difluoro[(2-hydroxyethyl)thio]acetic Acid Ethyl Ester; Ethyl Difluoro[(2-Hydroxyethyl)Sulfanyl]Acetate; Acetic Acid, 2-[(2-Hydroxyethyl)thio]-2,2-difluoro-, Ethyl Ester
EINECS	Contact for details

Quality Control

Every batch of Acetic Acid, Difluoro[(2-Hydroxyethyl)Thio]-, Ethyl Ester (9Ci) is produced and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical research and development applications. A detailed Certificate of Analysis (COA) including results from NMR, HPLC, and GC analysis is supplied with each shipment to guarantee it meets your specified requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is sensitive to strong bases and fluorides; keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.