Description

Nicotinonitrile, 1,4,5,6-Tetrahydro-2-Hydroxy-4-Methyl-6-Oxo-4-(Trifluoromethyl)- (8Ci) is a high-value, advanced pharmaceutical intermediate characterized by its unique trifluoromethyl-substituted dihydropyridone structure. This compound is essential for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and antiviral therapeutics. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its versatile chemical scaffold.
• Process Chemistry Development: Serves as a critical starting material for scaling up the production of target APIs under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Research: Potential intermediate in the development of novel pesticides and herbicides leveraging the trifluoromethyl group for enhanced bioactivity.
• Material Science: Investigated as a precursor for specialty chemicals and functional materials.

Basic Information

Item	Details
Product Name	Nicotinonitrile, 1,4,5,6-Tetrahydro-2-Hydroxy-4-Methyl-6-Oxo-4-(Trifluoromethyl)- (8Ci)
CAS No.	802565-31-7
Molecular Formula	C8H7F3N2O2
Molecular Weight	220.15 g/mol
Synonyms	1,4,5,6-Tetrahydro-2-hydroxy-4-methyl-6-oxo-4-(trifluoromethyl)nicotinonitrile; 4-Methyl-6-oxo-4-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-2-carbonitrile; 2-Hydroxy-4-methyl-6-oxo-4-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carbonitrile; Trifluoromethyl Dihydropyridone Nitrile; Advanced Trifluoromethyl Pyridone Intermediate; CAS 802565-31-7
EINECS	Contact for details

Quality Control

Every batch of Nicotinonitrile, 1,4,5,6-Tetrahydro-2-Hydroxy-4-Methyl-6-Oxo-4-(Trifluoromethyl)- (8Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting your regulatory filings and process validation. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting critical parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.