Description

1-(4-Bromo-2-Fluorophenyl)-2-Methylpropan-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its distinct halogenated aromatic ketone structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and other fine chemicals, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific bromo-fluoro substitution patterns into target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging its halogenated aromatic core.
• Material Science Research: Serves as a precursor for the development of specialty polymers and liquid crystals.
• Organic Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and as a substrate for further functionalization in academic and industrial labs.
• Chemical Reference Standard: Used for analytical method development, validation, and quality control in manufacturing environments.

Basic Information

Product Name	1-(4-Bromo-2-Fluorophenyl)-2-Methylpropan-1-One
CAS No.	801303-32-2
Molecular Formula	C10H10BrFO
Molecular Weight	245.09 g/mol
Synonyms	4'-Bromo-2'-fluoro-2-methylpropiophenone; 2-Methyl-1-(4-bromo-2-fluorophenyl)propan-1-one; 1-(4-Bromo-2-fluorophenyl)-2-methyl-1-propanone; p-Bromo-o-fluoroisobutyrophenone; α,α-Dimethyl-4-bromo-2-fluorobenzeneacetyl; Isobutyryl-4-bromo-2-fluorobenzene
EINECS	Contact for details

Quality Control

Our 1-(4-Bromo-2-Fluorophenyl)-2-Methylpropan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.