Description

3-(Trifluoromethoxy)Benzyl Chloride is a versatile and high-value fluorinated aromatic building block essential for advanced organic synthesis. Its core value proposition lies in the introduction of the reactive benzyl chloride group and the stable, lipophilic trifluoromethoxy moiety, enabling the construction of complex molecules with enhanced properties. This intermediate is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials industries for developing new active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides where the trifluoromethoxy group improves biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, enhancing charge transport and thermal stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart unique solubility, chemical resistance, and surface properties.
• Cross-coupling Reactions: Utilized in palladium-catalyzed reactions (e.g., Suzuki, Heck) to create complex biaryl structures for drug discovery.
• Ligand & Catalyst Development: Acts as a starting material for synthesizing novel fluorinated ligands used in asymmetric catalysis.

Basic Information

Product Name	3-(Trifluoromethoxy)Benzyl Chloride
CAS No.	89807-43-2
Molecular Formula	C8H6ClF3O
Molecular Weight	210.58 g/mol
Synonyms	α-Chloro-3-(trifluoromethoxy)toluene; 1-(Chloromethyl)-3-(trifluoromethoxy)benzene; m-(Trifluoromethoxy)benzyl chloride; 3-(Trifluoromethoxy)phenylmethyl chloride; (3-Trifluoromethoxyphenyl)methyl chloride; α-Chloro-α-(trifluoromethoxy)toluene; 3-(Trifluoromethoxy)benzylchloride
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethoxy)Benzyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.