Description

1,1,1-Trifluoro-3-Mercaptophenylacetone is a specialized organofluorine building block featuring both a trifluoromethyl group and a reactive thiol moiety. This compound is valued for its role in introducing fluorine atoms and sulfur-based functional groups into target molecules, which can significantly alter their physicochemical and biological properties. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated drug candidates, particularly in areas like oncology, CNS disorders, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the trifluoromethyl group can enhance bioavailability and stability.
• Material Science Precursor: Serves as a monomer or modifier in the development of specialty polymers and advanced materials with unique surface properties.
• Ligand and Catalyst Development: The thiol group allows for the creation of novel ligands for metal catalysis or surface functionalization in nanotechnology.
• Chemical Biology Probes: Employed in the design of activity-based probes and bioconjugation reagents for studying biological systems.
• Custom Synthesis and R&D: A versatile reagent for contract research organizations (CROs) and academic laboratories exploring new fluorination and thiol-chemistry methodologies.

Basic Information

Product Name	1,1,1-Trifluoro-3-Mercaptophenylacetone
CAS No.	89360-52-1
Molecular Formula	C10H9F3OS
Molecular Weight	234.24 g/mol
Synonyms	3-Mercapto-1,1,1-trifluoro-4-phenylbutan-2-one; 1,1,1-Trifluoro-4-phenyl-3-mercaptobutan-2-one; 3-Mercapto-1,1,1-trifluorophenylacetone; α-(Trifluoromethyl)-β-mercaptostyryl methyl ketone; TFMPA-Thiol; Phenylacetone, 3-mercapto-1,1,1-trifluoro-; 89360-52-1 (CAS)
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoro-3-Mercaptophenylacetone is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, minimize headspace and exposure to air after opening.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.