Description

21-o-Acetyl-21-o-De(3-Carboxy-1-Oxo-2-Propenyl)-2-Demethyl-2-Methoxy-24-Methylhygrolidin is a structurally complex, semi-synthetic macrolide derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard for the synthesis and study of novel bioactive molecules, particularly within the antibiotic and antifungal domains. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthetic pathway for novel macrolide antibiotics and antifungal agents.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and reduce toxicity.
• Biochemical Research: Investigated for its mechanism of action and interaction with biological targets such as ribosomes.
• Process Development: Employed in scaling up and optimizing synthetic routes for cost-effective production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	21-o-Acetyl-21-o-De(3-Carboxy-1-Oxo-2-Propenyl)-2-Demethyl-2-Methoxy-24-Methylhygrolidin
CAS No.	88899-58-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	21-O-Acetyl-21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methylhygrolidin; 2-Demethyl-2-methoxy-24-methylhygrolidin 21-acetate derivative; Hygrolidin derivative, 21-O-acetyl-21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-; A derivative of the macrolide antibiotic hygrolidin.
EINECS	Contact for details

Quality Control

Our 21-o-Acetyl-21-o-De(3-Carboxy-1-Oxo-2-Propenyl)-2-Demethyl-2-Methoxy-24-Methylhygrolidin is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, spectroscopic identification (IR, NMR), and residual solvent analysis, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.