Description

[3Ar,4R,5E,9E,11As,(-)]-4-(Acetyloxy)-3A,4,7,8,11,11A-Hexahydro-10-(Hydroxymethyl)-6-Methyl-3-Methylenecyclodeca[B]Furan-2(3H)-One is a complex, high-purity sesquiterpene lactone derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated chemical building block and intermediate for research and development in specialized pharmaceutical and agrochemical applications. It is primarily needed by R&D chemists and process development scientists working on novel active ingredients, particularly those exploring natural product-inspired scaffolds with potential biological activity.

Application

This specialized chemical intermediate serves critical functions in advanced research and development settings:

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the synthesis of novel drug candidates, especially those with complex polycyclic frameworks.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging its unique sesquiterpene structure.
• Natural Product Synthesis: Serves as a crucial building block for the total or semi-synthesis of complex natural products and their analogues.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore new chemical spaces for biological targets.
• Process Chemistry Development: Used for scaling up synthetic routes and optimizing reaction conditions for the production of high-value target molecules.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in related compound analysis.

Basic Information

Product Name	[3Ar,4R,5E,9E,11As,(-)]-4-(Acetyloxy)-3A,4,7,8,11,11A-Hexahydro-10-(Hydroxymethyl)-6-Methyl-3-Methylenecyclodeca[B]Furan-2(3H)-One
CAS No.	88861-90-9
Molecular Formula	C17H22O5
Molecular Weight	306.36 g/mol
Synonyms	(-)-4-Acetoxy-10-hydroxymethyl-6-methyl-3-methylidene-3a,4,7,8,11,11a-hexahydrocyclodeca[b]furan-2-one; 4-Acetyloxy-3a,4,7,8,11,11a-hexahydro-10-hydroxymethyl-6-methyl-3-methylidene-cyclodeca[b]furan-2-one; Parthenolide derivative; Parthenolide analogue; Sesquiterpene lactone acetate; Helenalin derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

We maintain stringent quality standards for our advanced intermediates. Our products undergo rigorous quality testing, including identity confirmation by spectroscopic methods (NMR, IR, MS) and purity assessment by HPLC, to ensure batch-to-batch consistency and compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.