Description

L-Glutamic Acid, n-[(Phenylmethoxy)Carbonyl]-, 1-(1-Methylethyl) Ester is a protected derivative of the essential amino acid L-glutamic acid, featuring a Cbz (carboxybenzyl) protecting group on the amine and an isopropyl ester on the carboxylic acid. This compound matters as a crucial chiral building block in organic synthesis, enabling the controlled construction of complex peptides and other biologically active molecules without racemization. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of peptide-based drugs, diagnostic agents, and advanced research compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of therapeutic peptides and peptidomimetics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate protected glutamic acid residues.
• Bioconjugation: Serves as a linker or spacer molecule in the design of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Research: Employed in the synthesis of custom peptides for studying protein-protein interactions and enzyme mechanisms.
• Protecting Group Strategy: Utilized in complex organic syntheses where orthogonal protection of amino and carboxylic acid functionalities is required.
• Reference Standard: Acts as a high-purity analytical standard for quality control in peptide API manufacturing.

Basic Information

Product Name	L-Glutamic Acid, n-[(Phenylmethoxy)Carbonyl]-, 1-(1-Methylethyl) Ester
CAS No.	88815-54-7
Molecular Formula	C16H21NO6
Molecular Weight	323.34 g/mol
Synonyms	N-Cbz-L-glutamic acid α-isopropyl ester; Nα-Carbobenzoxy-L-glutamic acid 1-isopropyl ester; Z-L-Glu(OiPr)-OH; (S)-5-Isopropoxy-4-((((benzyloxy)carbonyl)amino)-5-oxopentanoic acid; N-[(Benzyloxy)carbonyl]-L-glutamic acid 1-isopropyl ester; Cbz-L-Glutamic acid α-isopropyl ester; L-Glutamic acid, N-[(phenylmethoxy)carbonyl]-, 1-(1-methylethyl) ester; Z-Glu(OiPr)-OH
EINECS	Contact for details

Quality Control

Our L-Glutamic Acid, n-[(Phenylmethoxy)Carbonyl]-, 1-(1-Methylethyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chiral purity and chemical assay, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.