Description

(S)-Nicotine Dicitrate CAS NO 88660-51-9 is a high-purity, enantiomerically pure salt form of nicotine, specifically the (S)-enantiomer complexed with citric acid. This compound is critical for research and development requiring precise stereochemical control, as it represents the naturally occurring and biologically active form of nicotine. It is primarily utilized by the pharmaceutical, biotechnology, and advanced agrochemical industries for applications ranging from analytical standards and reference materials to the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Serves as a primary analytical standard for the quantification and qualification of nicotine and its derivatives in drug formulations and pharmacokinetic studies.
• Biomedical Research: Used in neuropharmacology and behavioral studies to investigate nicotinic acetylcholine receptor (nAChR) function, addiction mechanisms, and cognitive processes.
• Active Pharmaceutical Ingredient (API) Intermediate: A key chiral building block in the synthesis of advanced nicotine replacement therapies (NRTs) and other investigational drugs targeting the central nervous system.
• Analytical Chemistry: Employed as a calibrant in high-performance liquid chromatography (HPLC), gas chromatography (GC), and mass spectrometry (MS) methods for forensic, clinical, and quality control laboratories.
• Agrochemical Research: Used in the development of next-generation, enantiomerically pure insecticides and pest control agents that mimic natural plant alkaloids.
• E-liquid and Advanced Inhalation Product Formulation: Provides a controlled, high-purity source of nicotine for research into reduced-risk tobacco products and medicinal inhalers.

Basic Information

Product Name	(S)-Nicotine Dicitrate
CAS No.	88660-51-9
Molecular Formula	C10H14N2 · 2C6H8O7
Molecular Weight	590.55 g/mol
Synonyms	(S)-Nicotine Dicitrate Salt; (-)-Nicotine Dicitrate; (S)-(-)-Nicotine Dicitrate; L-Nicotine Dicitrate; Nicotine Dicitrate Salt; Nicotine Hydrogen Citrate; Nicotine Citrate (2:1); 3-[(2S)-1-Methylpyrrolidin-2-yl]pyridine dicitrate
EINECS	Contact for details

Quality Control

Our (S)-Nicotine Dicitrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet stringent specifications. We provide full traceability and Certificates of Analysis (COA) detailing results for key parameters such as assay (HPLC), chiral purity, residual solvents, and heavy metals. Our quality commitment supports applications requiring compliance with cGMP, ICH guidelines, and pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥ 99.0% (S)-isomer
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.