Description

3,5-Bis(Trifluoromethyl)Phenylacetylene is a high-value fluorinated aromatic building block characterized by its electron-deficient phenyl ring and terminal alkyne functionality. This compound matters for its critical role in advanced organic synthesis, particularly in cross-coupling reactions to construct complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and specialty polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of biologically active molecules, including kinase inhibitors and other targeted therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides with enhanced efficacy and environmental profiles.
• Material Science: Serves as a monomer or cross-linker in the production of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Catalyst Ligand Precursor: Employed in the synthesis of sophisticated ligand systems for transition metal catalysis.
• Chemical Research: A versatile building block for Sonogashira, Click, and other cross-coupling reactions in academic and industrial R&D settings.
• Fluorinated Compound Library: Essential for creating diverse screening libraries in drug discovery programs.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Phenylacetylene
CAS No.	88444-81-9
Molecular Formula	C10H4F6
Molecular Weight	238.13 g/mol
Synonyms	1-Ethynyl-3,5-bis(trifluoromethyl)benzene; 3,5-Bis(trifluoromethyl)phenylacetylene; 3,5-Bis(trifluoromethyl)ethynylbenzene; 3,5-Di(trifluoromethyl)phenylacetylene; 3,5-Bis(trifluoromethyl)benzenacetylene; 3,5-Bis(trifluoromethyl)acetylene benzene; 3,5-Bis(trifluoromethyl)ethynyl-benzene
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Phenylacetylene is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.