Description

n-(tert-Butoxycarbonyl)Glycyl-4-Nitro-3-Phenyl-L-Alanyl-L-Prolinamide is a specialized, Boc-protected peptide building block used in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity intermediates to construct complex peptide sequences with precise stereochemistry. It is primarily utilized in pharmaceutical R&D for the development of novel therapeutic peptides, protease inhibitors, and biochemical probes.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex therapeutic peptides targeting various diseases.
• Protease Inhibitor Research: Used in the design and development of peptide-based enzyme inhibitors for biochemical studies.
• Solid-Phase Peptide Synthesis (SPPS): An essential, protected amino acid derivative for the sequential assembly of custom peptide chains.
• Bioconjugation & Labeling: Serves as a precursor for creating labeled peptides for diagnostic imaging or assay development.
• Academic & Contract Research: Employed in university and CRO laboratories for fundamental peptide chemistry and drug discovery projects.
• API Development: Used in the process development and scale-up of Active Pharmaceutical Ingredients (APIs) with peptide motifs.

Basic Information

Product Name	n-(tert-Butoxycarbonyl)Glycyl-4-Nitro-3-Phenyl-L-Alanyl-L-Prolinamide
CAS No.	88331-08-2
Molecular Formula	C25H35N5O7
Molecular Weight	517.58 g/mol
Synonyms	Boc-Gly-(4-NO2-3-Ph-Phe)-Pro-NH2; Boc-Gly-4-Nitro-3-phenyl-L-phenylalanyl-L-prolinamide; (2S)-1-[(2S)-2-[[(2S)-2-[(2-[(tert-Butoxycarbonyl)amino]acetyl)amino]-3-(4-nitro-3-phenylphenyl)propanoyl]amino]pyrrolidin-1-yl]-1-oxopropan-2-aminium; Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, (2S)-1-[(2S)-2-[[(2S)-2-[(2-[[(1,1-dimethylethoxy)carbonyl]amino]acetyl)amino]-3-[3-(4-nitrophenyl)phenyl]propanoyl]amino]-1-(aminocarbonyl)propyl]-2-pyrrolidinecarboxamide; Boc-Gly-4-Nitro-3-Phe-Pro-NH2; Peptide Synthesis Intermediate 88331-08-2
EINECS	Contact for details

Quality Control

Our n-(tert-Butoxycarbonyl)Glycyl-4-Nitro-3-Phenyl-L-Alanyl-L-Prolinamide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH limits
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.