Description

trans-3-Methylcyclobutanecarboxylic Acid is a specialized cyclobutane derivative carboxylic acid with a defined stereochemistry. This compound serves as a valuable chiral building block and intermediate in advanced organic synthesis, prized for its rigid, strained cyclobutane ring structure. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides with enhanced stereospecificity and biological activity.
• Ligand and Catalyst Development: Precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Monomer or modifier for developing polymers with unique thermal and mechanical properties derived from the strained ring system.
• Flavor & Fragrance Chemistry: Intermediate for the synthesis of complex, stereochemically defined aroma compounds.
• Academic & Industrial R&D: Reference standard and starting material for methodological studies in organic synthesis and stereochemistry.

Basic Information

Product Name	trans-3-Methylcyclobutanecarboxylic Acid
CAS No.	87863-09-0
Molecular Formula	C6H10O2
Molecular Weight	114.14 g/mol
Synonyms	(1r,3r)-3-Methylcyclobutanecarboxylic Acid; trans-3-Methylcyclobutanecarboxylic Acid; (R,R)-3-Methylcyclobutanecarboxylic Acid; 3-Methylcyclobutanecarboxylic Acid, trans-; 3-Methylcyclobutanecarboxylic Acid; Cyclobutanecarboxylic acid, 3-methyl-, trans-; (1R,3R)-rel-3-Methylcyclobutanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our trans-3-Methylcyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and stereochemical integrity. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing results from chiral HPLC, NMR, and other relevant tests to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. The product is moisture-sensitive; keep container tightly sealed under an inert atmosphere for optimal shelf life.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.