Description

4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzyl Alcohol is a specialized diazirine-based photoaffinity labeling reagent, a critical tool for probing biomolecular interactions and mapping binding sites. Its trifluoromethyl diazirine group generates highly reactive carbenes upon UV irradiation, enabling covalent cross-linking to target proteins or nucleic acids with high efficiency. This compound is essential for researchers and manufacturers in pharmaceutical discovery, chemical biology, and proteomics who require reliable, high-purity building blocks for developing novel therapeutics and diagnostic agents.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalent capture and identification of drug-protein or protein-protein interaction sites in drug discovery pipelines.
• Chemical Probe Synthesis: Used as a versatile intermediate for synthesizing advanced chemical probes to study enzyme mechanisms and cellular pathways.
• Proteomics Research: Integral to activity-based protein profiling (ABPP) and target identification studies, helping to elucidate protein function.
• Bioconjugation: Serves as a photoreactive handle for the site-specific modification of biomolecules, antibodies, or nanoparticles.
• Material Science: Potential use in developing photo-crosslinkable polymers and surface functionalization for specialized coatings.
• Academic & Industrial R&D: A fundamental research chemical for universities, CROs (Contract Research Organizations), and biotech companies exploring new biological targets.

Basic Information

Product Name	4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzyl Alcohol
CAS No.	87736-88-7
Molecular Formula	C9H7F3N2O
Molecular Weight	216.16 g/mol
Synonyms	(3-(Trifluoromethyl)diazirin-3-yl)phenylmethanol; 3-[4-(Hydroxymethyl)phenyl]-3-(trifluoromethyl)-3H-diazirine; 4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)benzenemethanol; p-(3-(Trifluoromethyl)-3H-diazirin-3-yl)benzyl alcohol; Benzyl alcohol, 4-[3-(trifluoromethyl)-3H-diazirin-3-yl]-; Photoaffinity labeling reagent; Trifluoromethyl phenyl diazirine benzyl alcohol
EINECS	Contact for details

Quality Control

Every batch of 4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzyl Alcohol is manufactured and tested under strict quality management systems to ensure consistency and reliability for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity confirmation, and impurity profiles. Our quality commitment aligns with the standards expected in pharmaceutical R&D and fine chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.