Description

3-(4-Methylphenyl)-3-(Trifluoromethyl)Diazirine is a specialized diazirine-based photoaffinity labeling reagent. This compound is valued for its ability to generate highly reactive carbene intermediates upon photolysis, enabling covalent cross-linking with target biomolecules. It is primarily utilized by researchers and manufacturers in the life sciences and pharmaceutical industries for advanced biochemical studies, including protein-protein interaction mapping and drug target identification.

Application

• Photoaffinity Labeling (PAL): A critical reagent for covalent tagging of biological targets in proteomics and structural biology research.
• Chemical Biology Probes: Used to synthesize probes for investigating enzyme active sites, receptor binding pockets, and other macromolecular interactions.
• Drug Discovery: Employed in target identification and validation studies to understand drug mechanism of action.
• Bioconjugation: Facilitates the site-specific labeling of proteins, nucleic acids, and other biomolecules for imaging and diagnostic applications.
• Materials Science: Applied in surface functionalization and the development of photo-crosslinkable polymers and advanced materials.

Basic Information

Product Name	3-(4-Methylphenyl)-3-(Trifluoromethyl)Diazirine
CAS No.	87736-85-4
Molecular Formula	C9H7F3N2
Molecular Weight	200.16 g/mol
Synonyms	3-(p-Tolyl)-3-(trifluoromethyl)diazirine; 4-Methylbenzene, 1-[3-(trifluoromethyl)-3H-diazirin-3-yl]-; 3-(4-Methylphenyl)-3-(trifluoromethyl)-3H-diazirine; p-Methylphenyl(trifluoromethyl)diazirine; TPD; Trifluoromethyl p-tolyldiazirine; Photoaffinity Labeling Reagent TPD; 3-Trifluoromethyl-3-(p-tolyl)diazirine
EINECS	Contact for details

Quality Control

Our 3-(4-Methylphenyl)-3-(Trifluoromethyl)Diazirine is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability data. We adhere to relevant quality management standards to guarantee supply reliability and product integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at recommended temperatures (typically 2-8°C or as specified on the label). This product is strictly light-sensitive and must be protected from all light exposure during storage and handling to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.