Description

Clerocidin CAS NO 87501-14-2 is a potent diterpenoid antibiotic compound known for its unique mechanism of action as a topoisomerase II inhibitor. This specialized chemical is valued in research and development for its ability to induce DNA cleavage and study enzyme interactions. It serves as a critical tool compound for pharmaceutical researchers, microbiologists, and biochemists investigating novel antibacterial agents, cancer therapeutics, and DNA replication processes.

Application

• Biochemical Research: Used as a specific inhibitor to study the function and mechanism of topoisomerase II enzymes in DNA replication and transcription.
• Antibacterial Agent Development: Serves as a lead compound or reference standard in the discovery and synthesis of new antibiotic classes targeting resistant bacterial strains.
• Oncology Research: Investigated for its potential as an anticancer agent due to its DNA-damaging properties and ability to induce apoptosis in tumor cells.
• Molecular Biology: Employed in assays to probe DNA-protein interactions and to understand the cellular response to DNA double-strand breaks.
• Pharmaceutical Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in drug discovery pipelines.
• Microbiology Studies: Applied in research to understand bacterial cell death mechanisms and to evaluate the efficacy of antimicrobial compounds.

Basic Information

Product Name	Clerocidin
CAS No.	87501-14-2
Molecular Formula	C22H30O7
Molecular Weight	406.47 g/mol
Synonyms	(-)-Clerocidin; Antibiotic U-59,587; U-59587; 3,12-Epoxy-6,7-seco-6,20-epoxy-7,20-olide-12,14-podocarpa-8,11,13-trien-16-oic acid, 13-ethyl-4-hydroxy-5,9-dimethyl-13-methyl-, δ-lactone, (4R,5R,12R,13S)-
EINECS	Contact for details

Quality Control

Our Clerocidin is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing specific results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.