Description

2'-Chloro-6'-Fluoroacetophenone is a high-purity, versatile aromatic ketone building block essential for advanced organic synthesis. Its unique halogenated structure makes it a critical intermediate for developing active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a building block for developing advanced herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Intermediate for synthesizing functionalized polymers and advanced organic electronic materials.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.
• Academic and R&D Laboratories: Utilized in methodological research for new coupling reactions and heterocycle formation.

Basic Information

Product Name	2'-Chloro-6'-Fluoroacetophenone
CAS No.	87327-69-3
Molecular Formula	C8H6ClFO
Molecular Weight	172.58 g/mol
Synonyms	1-(2-Chloro-6-fluorophenyl)ethanone; 2-Chloro-6-fluoroacetophenone; 2-Chloro-6-fluorophenylethanone; 2'-Chloro-6'-fluorophenylethanone; 1-Acetyl-2-chloro-6-fluorobenzene; α-Chloro-α'-fluoroacetophenone; 87327-69-3 (CAS Registry)
EINECS	Contact for details

Quality Control

Our 2'-Chloro-6'-Fluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.