Description

3-Trimethylsilylpropargyl Aldehyde Diethyl Acetal is a versatile organosilicon building block featuring both a protected aldehyde and a terminal alkyne functional group. This bifunctional nature makes it a critical intermediate for the synthesis of complex molecules, enabling advanced carbon chain elongation and heterocycle formation. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly in the synthesis of compounds with alkyne and aldehyde-derived moieties.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators requiring specific silicon-containing scaffolds.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers, silicones, and advanced organic-inorganic hybrid materials.
• Organic Synthesis Building Block: Employed in Sonogashira coupling, click chemistry, and other metal-catalyzed reactions to introduce propargylic and silyl-protected functionalities.
• Ligand and Catalyst Development: Useful for synthesizing novel chelating ligands and organometallic catalysts used in asymmetric synthesis.
• Fluorescent Probe and Dye Chemistry: Acts as a starting material for creating conjugated systems and fluorophores used in bioimaging and sensors.

Basic Information

Product Name	3-Trimethylsilylpropargyl Aldehyde Diethyl Acetal
CAS No.	87219-80-5
Molecular Formula	C11H22O2Si
Molecular Weight	214.38 g/mol
Synonyms	3-[(Diethoxy)methyl]-1-trimethylsilyl-1-propyne; 1-Trimethylsilyl-3,3-diethoxy-1-propyne; Propargylaldehyde diethyl acetal, 3-trimethylsilyl-; 3,3-Diethoxy-1-trimethylsilyl-1-propyne; (3,3-Diethoxyprop-1-yn-1-yl)trimethylsilane; TMS-Propargyl Aldehyde Diethyl Acetal; Trimethyl(3,3-diethoxyprop-1-yn-1-yl)silane
EINECS	Contact for details

Quality Control

Every batch of 3-Trimethylsilylpropargyl Aldehyde Diethyl Acetal is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical synthetic applications. Certificates of Analysis (COA) detailing specifications such as assay (by GC or NMR), identity (IR, NMR), and purity are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.