Description

Cyclohexylboronic Acid Pinacol Ester is a protected boronic acid derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in its enhanced stability and handling characteristics compared to the free boronic acid, making it an indispensable reagent for Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent in Suzuki-Miyaura cross-coupling for constructing biaryl and alkyl-aryl bonds in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides that require the incorporation of cyclohexyl motifs.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Advanced Material Research: Employed in the creation of organic electronic materials, liquid crystals, and polymers where precise carbon-boron chemistry is needed.
• Chemical Biology & Proteomics: Utilized in the development of chemical probes and bioconjugation tools due to its selective reactivity.
• Scalable Process Chemistry: Preferred in kilo-lab and pilot plant scale-ups where the pinacol ester's stability offers advantages in storage, handling, and reaction consistency.

Basic Information

Product Name	Cyclohexylboronic Acid Pinacol Ester
CAS No.	87100-15-0
Molecular Formula	C12H23BO2
Molecular Weight	210.12 g/mol
Synonyms	Cyclohexylboronic Acid Pinacol Ester; Cyclohexyl-4,4,5,5-Tetramethyl-1,3,2-dioxaborolane; Cyclohexylboronic Acid, Pinacol Ester; Cyclohexyl-1,3,2-dioxaborolane, 4,4,5,5-tetramethyl-; Cyclohexylboronate Pinacol Ester; Cyclohexyl-Bpin; B-Cyclohexyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Cyclohexyl MIDA Boronate (Note: MIDA is a different protecting group, but sometimes listed in searches)
EINECS	Contact for details

Quality Control

Our Cyclohexylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality documentation to meet specific regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for prolonged use or when opening a new container to prevent hydrolysis and oxidation. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.