Description

Threo-(2Rs)-3-Acetylamino-2-Hydroxy-4-Oxo-4-Phenylbutyric Acid is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound is valued for its role as a key building block in the production of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular conditions. It is primarily required by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of novel therapeutics and process optimization.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of protease inhibitors and other complex drug molecules.
• API Development: Serves as a key building block in the research and production of new Active Pharmaceutical Ingredients (APIs).
• Biochemical Research: Used in academic and industrial laboratories for studying enzyme-substrate interactions and reaction mechanisms.
• Asymmetric Synthesis: Employed in stereoselective chemical reactions to introduce specific chiral centers into target molecules.
• Fine Chemical Production: Utilized in the manufacture of other high-value, specialized organic compounds.

Basic Information

Product Name	Threo-(2Rs)-3-Acetylamino-2-Hydroxy-4-Oxo-4-Phenylbutyric Acid
CAS No.	87081-54-7
Molecular Formula	C13H15NO5
Molecular Weight	265.26 g/mol
Synonyms	(2R,3S)-3-Acetamido-2-hydroxy-4-oxo-4-phenylbutanoic acid; (2R,3S)-3-Acetylamino-2-hydroxy-4-oxo-4-phenylbutyric acid; Threo-3-Acetylamino-2-hydroxy-4-oxo-4-phenylbutyric acid; 3-Acetamido-2-hydroxy-4-oxo-4-phenylbutanoic acid; N-Acetyl-L-threo-β-hydroxyaspartic acid β-phenyl ester; A key intermediate for protease inhibitors
EINECS	Contact for details

Quality Control

Our Threo-(2Rs)-3-Acetylamino-2-Hydroxy-4-Oxo-4-Phenylbutyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound may be hygroscopic; protect from moisture and store under inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.