Description

Ethanone, 1-(4-Acetylphenyl)-2,2,2-Trifluoro- (9Ci) is a specialized trifluoromethylated aromatic ketone, a key building block in advanced organic synthesis. This compound is valued for its unique molecular architecture, which introduces both ketone and trifluoromethyl functionalities onto a biphenyl-like core, enabling precise modifications to chemical and physical properties. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases, where the trifluoromethyl group can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms to improve lipophilicity and environmental persistence of active ingredients.
• Liquid Crystal & OLED Material Research: Acts as a key synthon for constructing fluorinated aromatic cores essential for high-performance electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Employed to incorporate fluorinated segments into polymer backbones, imparting desirable properties such as chemical resistance, thermal stability, and low surface energy for specialty coatings and engineering plastics.
• Chemical Research & Process Development: Utilized in academic and industrial laboratories for methodological studies in cross-coupling reactions, fluorination chemistry, and the development of new synthetic pathways.

Basic Information

Product Name	Ethanone, 1-(4-Acetylphenyl)-2,2,2-Trifluoro- (9Ci)
CAS No.	86988-49-0
Molecular Formula	C10H7F3O2
Molecular Weight	216.16 g/mol
Synonyms	1-(4-Acetylphenyl)-2,2,2-trifluoroethanone; 4-Acetyl-α,α,α-trifluoroacetophenone; 4'-Acetyl-2,2,2-trifluoroacetophenone; 2,2,2-Trifluoro-1-(4-acetylphenyl)ethanone; 4-Acetyl-α,α,α-trifluoroacetophenone; 1-[4-(Acetyl)phenyl]-2,2,2-trifluoroethanone; α,α,α-Trifluoro-4-acetylacetophenone
EINECS	Contact for details

Quality Control

Our Ethanone, 1-(4-Acetylphenyl)-2,2,2-Trifluoro- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing key specifications such as assay, impurity profile, and physical characteristics. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.