Description

4-Fluoro-3'-Trifluoromethylbiphenyl is a high-value fluorinated biphenyl derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethyl substituents, is engineered to impart enhanced metabolic stability, lipophilicity, and electronic properties to target molecules. This compound is essential for R&D and production chemists in the pharmaceutical and agrochemical industries, where it is utilized to develop novel active ingredients with improved performance profiles.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and manufacture of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the fluorine and CF3 groups.
• Liquid Crystal Materials: Serves as a core component or side-chain modifier in the synthesis of fluorinated liquid crystals for advanced display technologies.
• Organic Electronics: Acts as a precursor for electron-transport materials or host molecules in OLEDs and other organic semiconductor applications.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex polyaromatic systems.
• Material Science Research: Employed in the development of novel polymers, coatings, and specialty materials requiring specific fluorinated aromatic units.

Basic Information

Product Name	4-Fluoro-3'-Trifluoromethylbiphenyl
CAS No.	86967-67-1
Molecular Formula	C13H8F4
Molecular Weight	240.20 g/mol
Synonyms	3'-(Trifluoromethyl)-4-fluorobiphenyl; 4-Fluoro-3'-(trifluoromethyl)biphenyl; [1,1'-Biphenyl]-4-fluoro-3'-(trifluoromethyl)-; 4-Fluoro-3'-trifluoromethyl-1,1'-biphenyl; 3'-Trifluoromethyl-4-fluorobiphenyl; 4-Fluoro-α,α,α-trifluoro-3-biphenylmethane
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3'-Trifluoromethylbiphenyl is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.