Description

2-tert-Butoxycarbonylamino-3-(4-Nitro-Phenyl)-Propionic Acid CAS NO 86937-80-6 is a protected amino acid derivative, specifically a Boc-protected para-nitrophenylalanine analog, which serves as a critical building block in organic synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates for the construction of complex peptides and peptidomimetics. It is primarily utilized in pharmaceutical R&D for the synthesis of active pharmaceutical ingredients (APIs) and in academic settings for exploring novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide-based drugs and protease inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the para-nitrophenylalanine residue with orthogonal Boc protection.
• Chemical Biology Research: Employed in the development of enzyme substrates, fluorescent probes, and molecular tools that utilize the nitro group for further functionalization or as a spectroscopic handle.
• Material Science: Potential precursor for specialty polymers and advanced materials where aromatic nitro groups are required for subsequent reduction or cross-linking reactions.
• Agrochemical Synthesis: Intermediate in the research and development of novel agrochemicals with specific biological activity.

Basic Information

Product Name	2-tert-Butoxycarbonylamino-3-(4-Nitro-Phenyl)-Propionic Acid
CAS No.	86937-80-6
Molecular Formula	C14H18N2O6
Molecular Weight	310.30 g/mol
Synonyms	Boc-4-NO2-Phe-OH; Boc-p-Nitrophenylalanine; N-Boc-4-Nitro-L-phenylalanine; (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-nitrophenyl)propanoic Acid; 2-[(tert-Butoxycarbonyl)amino]-3-(4-nitrophenyl)propionic Acid; N-(tert-Butoxycarbonyl)-4-nitrophenylalanine; Boc-L-4-Nitrophenylalanine; 86937-80-6
EINECS	Contact for details

Quality Control

Our 2-tert-Butoxycarbonylamino-3-(4-Nitro-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the high standards required for pharmaceutical research and fine chemical synthesis. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and specific tests are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.