Description

(E)-tert-Butyl 4-Bromobut-2-Enoate is a high-purity, versatile building block in organic synthesis, valued for its reactive bromoalkene and ester functionalities. This compound is essential for facilitating key carbon-carbon bond formation and functional group transformations in complex molecule assembly. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of active pharmaceutical ingredients (APIs), specialty chemicals, and novel polymers.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs), particularly in cross-coupling and cyclization reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its reactivity to introduce specific molecular motifs.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced materials with tailored properties.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed reactions such as Heck, Suzuki, and Sonogashira couplings for constructing complex organic frameworks.
• Academic & R&D Laboratories: A valuable reagent for methodological development and exploring new synthetic pathways in organic chemistry.
• Fine Chemical Production: Employed in the custom synthesis of flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	(E)-tert-Butyl 4-Bromobut-2-Enoate
CAS No.	86606-04-4
Molecular Formula	C8H13BrO2
Molecular Weight	221.09 g/mol
Synonyms	tert-Butyl (2E)-4-bromo-2-butenoate; (E)-4-Bromo-2-butenoic acid tert-butyl ester; 4-Bromocrotonic acid tert-butyl ester; (2E)-4-Bromo-2-butenoic acid 1,1-dimethylethyl ester; 2-Butenoic acid, 4-bromo-, 1,1-dimethylethyl ester, (2E)-; t-Butyl 4-bromocrotonate; (E)-tert-Butyl 4-bromocrotonate
EINECS	Contact for details

Quality Control

Our (E)-tert-Butyl 4-Bromobut-2-Enoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure containers are kept tightly sealed to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Isomeric Purity (E/Z Ratio)	≥95:5 (by GC or HPLC)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.