Description

1,1,1-Trifluoro-4-Phenylbutan-2-One is a versatile fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the trifluoromethyl group, enabling the introduction of fluorine atoms to enhance the metabolic stability, lipophilicity, and bioavailability of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, particularly in CNS and oncology research.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where fluorine substitution improves efficacy and environmental profile.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals with tailored properties.
• Organic Synthesis Reagent: Employed in Friedel-Crafts acylation and other C-C bond-forming reactions to introduce the 4-phenyl-2-butanone scaffold.
• Fluorine Chemistry Research: A valuable compound for studying the effects of fluorine substitution on chemical reactivity and physical properties.
• Fine Chemical Production: Used in the multi-step synthesis of complex fragrance and flavor molecules.

Basic Information

Product Name	1,1,1-Trifluoro-4-Phenylbutan-2-One
CAS No.	86571-26-8
Molecular Formula	C10H9F3O
Molecular Weight	202.17 g/mol
Synonyms	4-Phenyl-1,1,1-trifluorobutan-2-one; 1,1,1-Trifluoro-4-phenyl-2-butanone; 4-Phenyl-2-trifluoroacetyl ethylbenzene; α,α,α-Trifluoro-4-phenyl-2-butanone; 4-Phenyl-2-butanone, 1,1,1-trifluoro-; TFAB; 86571-26-8 (CAS)
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoro-4-Phenylbutan-2-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.