Description

2-(Trimethylsilylethynyl)Pyridine is a specialized organosilicon building block featuring a pyridine ring linked to a trimethylsilyl-protected alkyne group. This compound matters as a versatile synthon in advanced organic synthesis, particularly for constructing complex molecular architectures via cross-coupling and click chemistry reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in creating advanced pesticide and herbicide molecules with tailored biological activity.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic electronic materials.
• Ligand Synthesis: Foundation for constructing sophisticated nitrogen-containing ligands used in catalysis and coordination chemistry.
• Cross-Coupling Reactions: The protected alkyne moiety is ideal for Sonogashira and other palladium-catalyzed coupling reactions to form conjugated systems.
• Academic & Industrial R&D: Essential reagent for methodological development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	2-(Trimethylsilylethynyl)Pyridine
CAS No.	86521-05-3
Molecular Formula	C11H15NSi
Molecular Weight	189.33 g/mol
Synonyms	2-[(Trimethylsilyl)ethynyl]pyridine; Pyridine, 2-[(trimethylsilyl)ethynyl]-; 2-Ethynylpyridine, trimethylsilyl derivative; 2-(Trimethylsilylethynyl)pyridine; 2-(TMS-ethynyl)pyridine; 2-Pyridyltrimethylsilylacetylene; TMS-2-Pyridylacetylene; 86521-05-3
EINECS	Contact for details

Quality Control

Our 2-(Trimethylsilylethynyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.