Description

2-(2,4-Dichloro-5-Fluoro-Benzoyl)-Malonic Acid Diethyl Ester is a high-purity, advanced pharmaceutical intermediate. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly fluoroquinolone antibiotics. It is primarily needed by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and fine chemical industries seeking reliable, high-quality raw materials for complex organic synthesis.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Serves as a crucial precursor in the synthesis of potent antibacterial agents like sitafloxacin and other advanced-generation quinolones.
• Organic Synthesis Building Block: Utilized in complex multi-step synthesis for constructing molecules containing the benzoyl-malonate moiety.
• Pharmaceutical R&D: Employed in research and process development for new drug candidates targeting bacterial infections.
• Fine Chemical Manufacturing: Used in the production of specialty chemicals requiring high-purity, structurally complex intermediates.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of APIs under cGMP conditions.

Basic Information

Product Name	2-(2,4-Dichloro-5-Fluoro-Benzoyl)-Malonic Acid Diethyl Ester
CAS No.	86483-50-3
Molecular Formula	C14H13Cl2FO5
Molecular Weight	363.16 g/mol
Synonyms	Diethyl 2-(2,4-dichloro-5-fluorobenzoyl)malonate; 2,4-Dichloro-5-fluorobenzoylmalonic Acid Diethyl Ester; Ethyl 2-(2,4-Dichloro-5-fluorobenzoyl)malonate; Malonic acid, (2,4-dichloro-5-fluorobenzoyl)-, diethyl ester; Diethyl (2,4-dichloro-5-fluorobenzoyl)malonate; 86483-50-3; Benzoylmalonic acid diethyl ester derivative
EINECS	Contact for details

Quality Control

Our 2-(2,4-Dichloro-5-Fluoro-Benzoyl)-Malonic Acid Diethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for pharmaceutical synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support development and commercial projects requiring material that meets in-house specifications or compendial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Store away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.