Description

((2R,3R)-3-[2-(tert-Butyl-Dimethyl-Silanyloxy)-Ethyl]-Oxiranyl)-Methanol is a high-purity, chiral epoxide intermediate featuring a tert-butyldimethylsilyl (TBDMS) protecting group. This compound matters for its role as a critical building block in the stereoselective synthesis of complex pharmaceutical molecules and fine chemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material industries seeking to introduce specific chiral centers with high enantiomeric purity.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of active pharmaceutical ingredients (APIs), particularly in antiviral, antifungal, and cardiovascular drug candidates.
• Asymmetric Synthesis: Used in stereocontrolled ring-opening reactions to construct complex molecular architectures with defined (2R,3R) stereochemistry.
• Natural Product Synthesis: Serves as a precursor in the total synthesis of complex natural products requiring specific epoxy alcohol functionalities.
• Agrochemical Research: Intermediate for developing chiral pesticides and herbicides where specific stereoisomers exhibit enhanced biological activity.
• Material Science: Potential monomer or cross-linking agent in the development of specialized polymers with tailored properties.
• Process Chemistry: Scalable intermediate for optimizing manufacturing routes under Current Good Manufacturing Practice (cGMP) conditions.

Basic Information

Product Name	((2R,3R)-3-[2-(tert-Butyl-Dimethyl-Silanyloxy)-Ethyl]-Oxiranyl)-Methanol
CAS No.	86462-76-2
Molecular Formula	C11H24O3Si
Molecular Weight	232.40 g/mol
Synonyms	(2R,3R)-3-[2-[(1,1-Dimethylethyl)dimethylsilyl]oxy]ethyl]oxiranylmethanol; (2R,3R)-3-[2-(tert-Butyldimethylsilyloxy)ethyl]oxiranylmethanol; (2R,3R)-3-[2-(TBDMS-oxy)ethyl]glycidol; (2R,3R)-TBDMS-Protected Glycidol Derivative; (2R,3R)-Epoxy Alcohol TBDMS Ether; (2R,3R)-3-(2-((tert-Butyldimethylsilyl)oxy)ethyl)oxiran-2-yl)methanol; (2R,3R)-Glycidyl TBDMS Ether Alcohol
EINECS	Contact for details

Quality Control

Our ((2R,3R)-3-[2-(tert-Butyl-Dimethyl-Silanyloxy)-Ethyl]-Oxiranyl)-Methanol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chiral purity. We provide comprehensive analytical data, including Chiral HPLC for enantiomeric excess (ee) verification and NMR for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.