Description

δ-(Spiro-4-Hydroxy-2,5-Cyclohexadienyl)Pyroglutamate is a specialized chiral building block and synthetic intermediate characterized by its unique spirocyclic structure. This compound is valued for its role in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for creating novel active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Asymmetric Synthesis: Used as a precursor or auxiliary in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity.
• Peptidomimetic Research: The pyroglutamate moiety makes it valuable for designing and synthesizing peptide analogs and mimetics with enhanced stability or bioavailability.
• Academic & Industrial R&D: Serves as a critical reagent in methodological development and exploratory chemistry within university and corporate research laboratories.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value specialty chemicals, agrochemicals, and advanced material precursors.

Basic Information

Product Name	δ-(Spiro-4-Hydroxy-2,5-Cyclohexadienyl)Pyroglutamate
CAS No.	86334-99-8
Molecular Formula	C11H13NO4
Molecular Weight	223.23 g/mol
Synonyms	δ-(Spiro-4-hydroxy-2,5-cyclohexadien-1-yl)-2-pyrrolidinone-5-carboxylic acid; (S)-5-Oxo-1-(spiro[2.5]octa-4,7-dien-6-yl)pyrrolidine-2-carboxylic acid; Spiro-Hydroxy-Cyclohexadienyl Pyroglutamate; 5-Oxoproline, 1-(spiro[2.5]octa-4,7-dien-6-yl)-, (S)-; 86334-99-8; (S)-1-(6-Hydroxyspiro[2.5]octa-4,7-dien-5-yl)-5-oxopyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our δ-(Spiro-4-Hydroxy-2,5-Cyclohexadienyl)Pyroglutamate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling, to ensure it meets the stringent requirements for research and development applications. Certificates of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), and specific test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.