Description

4-Methyl-[1,3,2]dioxaborinan-2-ol is a versatile organoboron compound, specifically a cyclic boronic ester, valued for its role as a key synthetic intermediate and protecting group. Its primary commercial significance lies in enabling precise chemical transformations, particularly in the synthesis of complex pharmaceutical molecules and advanced materials. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity boron reagents for cross-coupling reactions and other sophisticated organic syntheses.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially for Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require boron-containing motifs.
• Material Science Research: Serves as a precursor for boron-doped organic electronic materials and polymers.
• Organic Synthesis Reagent: Functions as a protected form of boronic acid, offering improved stability and handling characteristics in multi-step syntheses.
• Chemical Biology Probes: Utilized in the development of molecular probes and sensors that leverage boron's unique binding properties.
• Catalyst & Ligand Development: Acts as a starting material for creating novel boron-based catalysts and ligands for asymmetric synthesis.

Basic Information

Product Name	4-Methyl-[1,3,2]dioxaborinan-2-ol
CAS No.	86163-81-7
Molecular Formula	C5H11BO3
Molecular Weight	129.95 g/mol
Synonyms	4-Methyl-1,3,2-dioxaborinan-2-ol; 2-Hydroxy-4-methyl-1,3,2-dioxaborinane; 4-Methyl-2-hydroxy-1,3,2-dioxaborinane; Neopentyl glycol boronic ester; Neopentyl glycol boronates; Npg-B; 2-Borono-4-methyl-1,3,2-dioxaborinane; Pinanediol boronic ester analog
EINECS	Contact for details

Quality Control

Our 4-Methyl-[1,3,2]dioxaborinan-2-ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR, HPLC, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, this product should be handled and stored under an inert atmosphere (argon or nitrogen) when possible to maintain optimal stability and prevent hydrolysis. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.