Description

23-Hydroxyrosamicin is a chemically modified derivative of the macrolide antibiotic rosamicin, characterized by the introduction of a hydroxyl group at the 23-position. This structural modification is of significant interest for its potential to alter biological activity, pharmacokinetic properties, and spectrum of efficacy compared to the parent compound. It serves as a crucial pharmaceutical intermediate and research chemical for the development and study of novel antibacterial agents. This product is primarily utilized by R&D laboratories, academic institutions, and pharmaceutical companies engaged in antibiotic discovery and development.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthetic pathway for novel macrolide antibiotics.
• Antibacterial Research: Used in microbiological and biochemical studies to investigate structure-activity relationships (SAR) against resistant bacterial strains.
• Reference Standard: Employed as a certified reference material (CRM) in analytical laboratories for quality control and method validation.
• Medicinal Chemistry: A vital substrate for chemical modifications aimed at improving drug potency, reducing toxicity, or overcoming microbial resistance.
• Academic Research: Utilized in university and institutional research projects focused on antibiotic mechanisms of action and biosynthesis.
• Bioconjugation Studies: Potential use in creating antibody-drug conjugates (ADCs) or other targeted therapeutic constructs.

Basic Information

Product Name	23-Hydroxyrosamicin
CAS No.	86132-03-8
Molecular Formula	C35H61NO12
Molecular Weight	687.86 g/mol
Synonyms	23-Hydroxyrosamicin; Rosamicin, 23-hydroxy-; 23-Hydroxyrosamicin A; Antibiotic T-42082; (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one; 23-Hydroxyrosamicin (antibiotic); 23-OH-Rosamicin
EINECS	Contact for details

Quality Control

Our 23-Hydroxyrosamicin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (IR, NMR), and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to specifications. We support compliance with cGMP and ISO guidelines for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect the hygroscopic material from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.