Description

4-(4-Methylpiperidin-1-Yl)Benzaldehyde is a specialty heterocyclic aldehyde featuring a piperidine nitrogen linked via an aromatic spacer to a reactive formyl group. Its structural motif enables selective derivatization for bioactive molecule synthesis, offering high functional group compatibility and predictable reactivity under controlled conditions. This compound is critically valued by pharmaceutical R&D laboratories and fine chemical manufacturers developing CNS-active agents, kinase inhibitors, and GPCR-targeted therapeutics. It serves as a key building block in medicinal chemistry campaigns where conformationally constrained amine-aldehyde hybrids are required.

Application

• Intermediate in the synthesis of neurokinin-1 (NK1) receptor antagonists for antiemetic drug development
• Building block for piperidine-containing serotonin (5-HT3) receptor modulators
• Key precursor in the manufacture of selective dopamine D3 receptor ligands for neurological disorder research
• Chemical scaffold for structure–activity relationship (SAR) studies targeting σ-1 receptors
• Reagent in the preparation of photoactivatable crosslinkers for target engagement assays
• Intermediate in the production of PET radiotracer precursors (e.g., 11C- or 18F-labeled analogs)
• Substrate for asymmetric reductive amination to generate chiral piperidinyl benzylamines
• Functional handle in solid-phase synthesis of peptide–small molecule conjugates

Basic Information

Product Name	4-(4-Methylpiperidin-1-Yl)Benzaldehyde
CAS No.	85872-85-1
Molecular Formula	C13H17NO
Molecular Weight	203.28 g/mol
Synonyms	4-(4-Methyl-1-piperidinyl)benzaldehyde; 4-(4-Methylpiperidino)benzaldehyde; 4-(1-Methylpiperidin-4-yl)benzaldehyde; NSC 632952; UNII-53QZ7T9X4D; AKOS025710363; Z2920121407; 4-(4-Methylpiperidin-1-yl)benzaldehyde; 1-(4-Formylphenyl)-4-methylpiperidine; 4-[4-Methyl-1-piperidyl]benzaldehyde
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches meet stringent purity requirements for pharmaceutical intermediates, including full spectroscopic confirmation (IR, 1H NMR), residual solvent profiling per ICH Q3C guidelines, and heavy metal testing per USP General Chapter <232>. The material is manufactured under cGMP-aligned processes and conforms to REACH and FDA registration requirements for export to regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Avoid exposure to air and moisture due to susceptibility to oxidation. Do not store near strong oxidizing agents or alkaline materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Assay (HPLC)	≥ 98.5%
Identification (IR)	Conforms to reference standard
Identification (1H NMR)	Conforms to reference standard
Residue on Ignition	≤ 0.1%
Water (Karl Fischer)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Single impurity ≤ 0.3%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.