Description

[1R,6R,(+)]-1α-[[(1S,4Ar)-Decahydro-5,5,8Aβ-Trimethyl-2-Methylene-6-Oxonaphthalene-1β-Yl]Methyl]-5β-Hydroxy-4-(Hydroxymethyl)-7-Oxabicyclo[4.1.0]Hepta-3-Ene-2-One is a high-purity, complex sesquiterpene lactone derivative with significant synthetic utility. This compound serves as a critical chiral intermediate and building block in advanced organic synthesis, particularly for the development of novel bioactive molecules. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require high-quality, structurally defined intermediates for complex synthesis projects.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in anti-inflammatory and anticancer drug discovery.
• Agrochemical Synthesis: Used as a precursor in the synthesis of novel, biologically active compounds for crop protection and pest management solutions.
• Fine Chemical Production: Serves as a sophisticated building block for the synthesis of complex natural product analogs, flavors, and fragrances.
• Academic & Industrial Research: A valuable tool for methodological studies in asymmetric synthesis, catalysis, and total synthesis of complex organic molecules.
• Material Science Precursor: Potential use in the synthesis of specialized polymers or advanced materials with specific chiral properties.

Basic Information

Product Name	[1R,6R,(+)]-1α-[[(1S,4Ar)-Decahydro-5,5,8Aβ-Trimethyl-2-Methylene-6-Oxonaphthalene-1β-Yl]Methyl]-5β-Hydroxy-4-(Hydroxymethyl)-7-Oxabicyclo[4.1.0]Hepta-3-Ene-2-One
CAS No.	85764-12-1
Molecular Formula	C22H30O5
Molecular Weight	374.47 g/mol
Synonyms	(+)-1α-[[(1S,4aR)-Decahydro-5,5,8aβ-trimethyl-2-methylene-6-oxonaphthalen-1β-yl]methyl]-5β-hydroxy-4-(hydroxymethyl)-7-oxabicyclo[4.1.0]hept-3-ene-2-one; Parthenolide derivative; Sesquiterpene lactone intermediate; 7-Oxabicyclo[4.1.0]hepta-3-ene-2-one derivative; 1R,6R isomer; CAS 85764-12-1; (1R,6R)-enantiomer.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical characterization, including chiral purity verification, to ensure structural integrity and consistency. Certificates of Analysis (COA) detailing identity, purity (by HPLC), and impurity profiles are provided with every shipment. We support cGMP and ISO compliant manufacturing for critical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.