Description

1-(4-Bromo-1-Phenylbut-1-En-1-Yl)-4-Fluorobenzene is a specialized brominated and fluorinated aromatic building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring both a reactive bromoalkene moiety and a fluorinated phenyl ring, makes it a valuable precursor for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel drug candidates, particularly for introducing fluorinated aromatic systems and alkenyl halide handles for further cross-coupling reactions.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine atom can enhance biological activity, metabolic stability, and lipophilicity.
• Material Science Research: Acts as a monomer or precursor for synthesizing specialty polymers, liquid crystals, or organic electronic materials that require specific halogenated aromatic components.
• Cross-Coupling Reactions: The bromoalkene group is a versatile substrate for palladium-catalyzed reactions like Suzuki, Heck, or Sonogashira couplings, enabling rapid diversification of molecular structures.
• Chemical Biology Probes: Useful for synthesizing fluorescent tags or photoaffinity labels for studying biological systems, leveraging the reactivity of the bromine atom for bioconjugation.
• Catalyst Ligand Development: Can be utilized to develop novel phosphine or nitrogen-based ligands for asymmetric catalysis, with the fluorine atom fine-tuning electronic properties.

Basic Information

Product Name	1-(4-Bromo-1-Phenylbut-1-En-1-Yl)-4-Fluorobenzene
CAS No.	85375-29-7
Molecular Formula	C₁₆H₁₄BrF
Molecular Weight	305.19 g/mol
Synonyms	4-Bromo-1,1-diphenyl-1-butene-4-fluoro; 1-(4-Bromo-1-phenyl-1-buten-1-yl)-4-fluorobenzene; 4-Fluoro-1-(4-bromo-1-phenyl-1-buten-1-yl)benzene; (4-Bromo-1-phenyl-1-buten-1-yl)-4-fluorobenzene; 85375-29-7; 4-Bromo-1-(4-fluorophenyl)-1-phenyl-1-butene
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and process chemistry. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, impurities, and other critical parameters are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.