Description

(2S,3R,4R,4Aα,8Aβ)-3,4,4A,5,6,7,8,8A-Octahydro-2β,7β-Dihydroxy-4-[(Z)-3-Hydroxy-1-Oxo-2-Propenyl]-2α,4,5α,7α-Tetramethyl-3-[(R)-1-Methylpropyl]-1(2H)-Naphthalenone is a complex, stereochemically defined naphthalenone derivative that serves as a critical chiral building block and intermediate in advanced organic synthesis. Its intricate polycyclic structure with multiple stereocenters and functional groups makes it invaluable for constructing complex molecular architectures with high precision. This compound is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), natural product analogs, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, particularly in oncology and anti-inflammatory drug discovery.
• Natural Product Synthesis: Used as a sophisticated precursor in the total synthesis of complex natural products with biological activity.
• Asymmetric Catalysis Research: Serves as a substrate or ligand precursor in the development of new asymmetric catalytic reactions due to its multiple stereocenters.
• Fine Chemical Manufacturing: Employed in the production of high-value, specialty chemicals requiring specific stereochemistry.
• Academic & Industrial R&D: A valuable tool for chemists in both academic and industrial settings exploring new synthetic methodologies and structure-activity relationships.

Basic Information

Product Name	(2S,3R,4R,4Aα,8Aβ)-3,4,4A,5,6,7,8,8A-Octahydro-2β,7β-Dihydroxy-4-[(Z)-3-Hydroxy-1-Oxo-2-Propenyl]-2α,4,5α,7α-Tetramethyl-3-[(R)-1-Methylpropyl]-1(2H)-Naphthalenone
CAS No.	85269-25-6
Molecular Formula	C22H34O5
Molecular Weight	378.51 g/mol
Synonyms	1(2H)-Naphthalenone, 3,4,4a,5,6,7,8,8a-octahydro-2,7-dihydroxy-4-[(1Z)-3-hydroxy-1-oxo-2-propen-1-yl]-2,4,5,7-tetramethyl-3-(1-methylpropyl)-, (2S,3R,4R,4aR,8aS)-; (2S,3R,4R,4aR,8aS)-3,4,4a,5,6,7,8,8a-Octahydro-2,7-dihydroxy-4-[(1Z)-3-hydroxy-1-oxo-2-propen-1-yl]-2,4,5,7-tetramethyl-3-(1-methylpropyl)-1(2H)-naphthalenone; Polyhydroxylated Naphthalenone Derivative; Chiral Naphthalenone Intermediate.
EINECS	Contact for details

Quality Control

Our (2S,3R,4R,4Aα,8Aβ)-3,4,4A,5,6,7,8,8A-Octahydro-2β,7β-Dihydroxy-4-[(Z)-3-Hydroxy-1-Oxo-2-Propenyl]-2α,4,5α,7α-Tetramethyl-3-[(R)-1-Methylpropyl]-1(2H)-Naphthalenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure consistent identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing specific results for assay, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.