Description

o-Carboxyphenyl 5-Oxo-L-Prolinate is a high-purity, non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis. This compound matters as a versatile chiral building block, enabling the precise construction of complex molecular architectures. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel peptides, enzyme inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-based therapeutics.
• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies and proteomics research to investigate biological pathways.
• Organic Synthesis: Acts as a protected or modified proline analog for constructing complex organic molecules, including natural product analogs and macrocycles.
• Peptide Chemistry: Employed in solid-phase and solution-phase peptide synthesis to introduce constrained turn structures or modify peptide backbone properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying protein-protein interactions and cellular processes.

Basic Information

Product Name	o-Carboxyphenyl 5-Oxo-L-Prolinate
CAS No.	85153-77-1
Molecular Formula	C₁₃H₁₃NO₆
Molecular Weight	279.25 g/mol
Synonyms	5-Oxo-L-proline, 2-carboxyphenyl ester; (S)-5-Oxopyrrolidine-2-carboxylic acid 2-carboxyphenyl ester; L-Pyroglutamic acid salicylate ester; 2-((5-Oxo-L-prolyl)oxy)benzoic acid; o-(5-Oxo-L-prolinoxy)benzoic acid; Salicyl L-pyroglutamate; 85153-77-1
EINECS	Contact for details

Quality Control

Our o-Carboxyphenyl 5-Oxo-L-Prolinate is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.