Description

3',5'-Bis(Trifluoromethyl)Propiophenone is a high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its value lies in the unique reactivity and electronic properties imparted by the trifluoromethyl groups, enabling the creation of complex molecules with enhanced stability and bioavailability. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethylated aromatic motifs for metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the fluorine atoms contribute to biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or building block for creating specialty polymers, liquid crystals, and organic electronic materials with specific optical or electronic properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Stille couplings to construct complex biaryl systems.
• Organofluorine Chemistry: A valuable reagent for studying and introducing fluorinated groups into target molecules, a critical area in modern medicinal chemistry.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions.

Basic Information

Product Name	3',5'-Bis(Trifluoromethyl)Propiophenone
CAS No.	85068-34-4
Molecular Formula	C11H8F6O
Molecular Weight	270.17 g/mol
Synonyms	1-[3,5-Bis(trifluoromethyl)phenyl]-1-propanone; 3,5-Bis(trifluoromethyl)propiophenone; 3',5'-Di(trifluoromethyl)propiophenone; 1-Propanone, 1-[3,5-bis(trifluoromethyl)phenyl]-; 3,5-Bis(trifluoromethyl)phenyl ethyl ketone; α-Ethyl-3,5-bis(trifluoromethyl)benzyl alcohol (keto form); Ethyl 3,5-bis(trifluoromethyl)phenyl ketone
EINECS	Contact for details

Quality Control

Our 3',5'-Bis(Trifluoromethyl)Propiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.